New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
Identifieur interne : 000171 ( Main/Exploration ); précédent : 000170; suivant : 000172New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.
Auteurs : Aymen Ben Nejma [Tunisie] ; Asma Nguir [Tunisie] ; Hichem Ben Jannet [Tunisie] ; M'Hamed Ali Hamza [Tunisie] ; Adam Daïch [France] ; Mohamed Othman [France] ; Ata Martin Lawson [France]Source :
- Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2015.
English descriptors
- KwdEn :
- Antioxidants (chemistry), Atriplex (chemistry), Atriplex (metabolism), Cholinesterases (chemistry), Cholinesterases (metabolism), Ecdysterone (analogs & derivatives), Ecdysterone (chemistry), Ecdysterone (metabolism), Ecdysterone (pharmacology), Gram-Negative Bacteria (drug effects), Gram-Positive Bacteria (drug effects), Magnetic Resonance Spectroscopy, Molecular Conformation, Plant Extracts (chemistry), Plant Roots (chemistry), Plant Roots (metabolism), Protein Binding.
- MESH :
- chemical , analogs & derivatives : Ecdysterone.
- chemical , chemistry : Antioxidants, Cholinesterases, Ecdysterone, Plant Extracts.
- chemistry : Atriplex, Plant Roots.
- drug effects : Gram-Negative Bacteria, Gram-Positive Bacteria.
- metabolism : Atriplex, Cholinesterases, Ecdysterone, Plant Roots.
- chemical , pharmacology : Ecdysterone.
- Magnetic Resonance Spectroscopy, Molecular Conformation, Protein Binding.
Abstract
The phytochemical investigation of a Tunisian plant Atriplex portulacoides (Chenopodiaceae) led to the isolation of two new compounds designated as portulasoid (2) and septanoecdysone (3) along with the known 20-hydroxyecdysone (20HE) (1). Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ES-HRMS, 1D and 2D-NMR. The isolated compounds were finally tested for their antioxidant activity by using DPPH, ABTS(+), Fe(3+) and catalase assays and also for their antibacterial and anticholinesterase activities.
DOI: 10.1016/j.bmcl.2015.03.028
PubMed: 25813159
Affiliations:
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Le document en format XML
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Electronic address: lawsona@univ-lehavre.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25813159</idno><idno type="pmid">25813159</idno><idno type="doi">10.1016/j.bmcl.2015.03.028</idno><idno type="wicri:Area/PubMed/Corpus">000093</idno><idno type="wicri:Area/PubMed/Curation">000093</idno><idno type="wicri:Area/PubMed/Checkpoint">000093</idno><idno type="wicri:Area/Ncbi/Merge">000466</idno><idno type="wicri:Area/Ncbi/Curation">000466</idno><idno type="wicri:Area/Ncbi/Checkpoint">000466</idno><idno type="wicri:Area/Main/Merge">000169</idno><idno type="wicri:Area/Main/Curation">000171</idno><idno type="wicri:Area/Main/Exploration">000171</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.</title><author><name sortKey="Ben Nejma, Aymen" sort="Ben Nejma, Aymen" uniqKey="Ben Nejma A" first="Aymen" last="Ben Nejma">Aymen Ben Nejma</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir</wicri:regionArea><wicri:noRegion>5019 Monastir</wicri:noRegion></affiliation></author><author><name sortKey="Nguir, Asma" sort="Nguir, Asma" uniqKey="Nguir A" first="Asma" last="Nguir">Asma Nguir</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir</wicri:regionArea><wicri:noRegion>5019 Monastir</wicri:noRegion></affiliation></author><author><name sortKey="Ben Jannet, Hichem" sort="Ben Jannet, Hichem" uniqKey="Ben Jannet H" first="Hichem" last="Ben Jannet">Hichem Ben Jannet</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia. Electronic address: hich.benjannet@yahoo.fr.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir</wicri:regionArea><wicri:noRegion>5019 Monastir</wicri:noRegion></affiliation></author><author><name sortKey="Hamza, M Hamed Ali" sort="Hamza, M Hamed Ali" uniqKey="Hamza M" first="M'Hamed Ali" last="Hamza">M'Hamed Ali Hamza</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir, University of Monastir, Avenue of Environment, 5019 Monastir</wicri:regionArea><wicri:noRegion>5019 Monastir</wicri:noRegion></affiliation></author><author><name sortKey="Daich, Adam" sort="Daich, Adam" uniqKey="Daich A" first="Adam" last="Daïch">Adam Daïch</name><affiliation wicri:level="4"><nlm:affiliation>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Othman, Mohamed" sort="Othman, Mohamed" uniqKey="Othman M" first="Mohamed" last="Othman">Mohamed Othman</name><affiliation wicri:level="4"><nlm:affiliation>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author><author><name sortKey="Lawson, Ata Martin" sort="Lawson, Ata Martin" uniqKey="Lawson A" first="Ata Martin" last="Lawson">Ata Martin Lawson</name><affiliation wicri:level="4"><nlm:affiliation>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex, France. Electronic address: lawsona@univ-lehavre.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>URCOM, EA 3221, INC3M CNRS FR-3038, UFR des Sciences et Techniques de l'Université du Havre, 25 Rue Philippe Lebon, B.P. 540, F-76058 Le Havre Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName><orgName type="university">Université du Havre</orgName></affiliation></author></analytic><series><title level="j">Bioorganic & medicinal chemistry letters</title><idno type="eISSN">1464-3405</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (chemistry)</term><term>Atriplex (chemistry)</term><term>Atriplex (metabolism)</term><term>Cholinesterases (chemistry)</term><term>Cholinesterases (metabolism)</term><term>Ecdysterone (analogs & derivatives)</term><term>Ecdysterone (chemistry)</term><term>Ecdysterone (metabolism)</term><term>Ecdysterone (pharmacology)</term><term>Gram-Negative Bacteria (drug effects)</term><term>Gram-Positive Bacteria (drug effects)</term><term>Magnetic Resonance Spectroscopy</term><term>Molecular Conformation</term><term>Plant Extracts (chemistry)</term><term>Plant Roots (chemistry)</term><term>Plant Roots (metabolism)</term><term>Protein Binding</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ecdysterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term><term>Cholinesterases</term><term>Ecdysterone</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Atriplex</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Atriplex</term><term>Cholinesterases</term><term>Ecdysterone</term><term>Plant Roots</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Ecdysterone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term><term>Molecular Conformation</term><term>Protein Binding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The phytochemical investigation of a Tunisian plant Atriplex portulacoides (Chenopodiaceae) led to the isolation of two new compounds designated as portulasoid (2) and septanoecdysone (3) along with the known 20-hydroxyecdysone (20HE) (1). Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ES-HRMS, 1D and 2D-NMR. The isolated compounds were finally tested for their antioxidant activity by using DPPH, ABTS(+), Fe(3+) and catalase assays and also for their antibacterial and anticholinesterase activities.</div></front></TEI><affiliations><list><country><li>France</li><li>Tunisie</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement><orgName><li>Université du Havre</li></orgName></list><tree><country name="Tunisie"><noRegion><name sortKey="Ben Nejma, Aymen" sort="Ben Nejma, Aymen" uniqKey="Ben Nejma A" first="Aymen" last="Ben Nejma">Aymen Ben Nejma</name></noRegion><name sortKey="Ben Jannet, Hichem" sort="Ben Jannet, Hichem" uniqKey="Ben Jannet H" first="Hichem" last="Ben Jannet">Hichem Ben Jannet</name><name sortKey="Hamza, M Hamed Ali" sort="Hamza, M Hamed Ali" uniqKey="Hamza M" first="M'Hamed Ali" last="Hamza">M'Hamed Ali Hamza</name><name sortKey="Nguir, Asma" sort="Nguir, Asma" uniqKey="Nguir A" first="Asma" last="Nguir">Asma Nguir</name></country><country name="France"><region name="Région Normandie"><name sortKey="Daich, Adam" sort="Daich, Adam" uniqKey="Daich A" first="Adam" last="Daïch">Adam Daïch</name></region><name sortKey="Lawson, Ata Martin" sort="Lawson, Ata Martin" uniqKey="Lawson A" first="Ata Martin" last="Lawson">Ata Martin Lawson</name><name sortKey="Othman, Mohamed" sort="Othman, Mohamed" uniqKey="Othman M" first="Mohamed" last="Othman">Mohamed Othman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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